I only shoot 22 cal now due to range availability and time. I'm a competition shooter (Olympic style prone - no scope, off of a sling & no additional support), shooting 25, 50 and 100yd.
On a good day 0.25 MOA isn't a problem at 100yd. Mostly 0.25 to 0.5 MOA at that range mind you.
Shoot a .22 well and you'll get a great foundation for any other rifle. I've gone on to shoot large cal up to 1200yd, but still find the requirements of small bore precision target shooting more challenging due to the ballistic properties.